Farzaneh Maryam, Attari Farnoosh, Khoshnam Seyed Esmaeil
1 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology , ACECR, Tehran, Iran .
2 Department of Animal Biology, School of Biology, College of Science, University of Tehran , Tehran, Iran .
Cell Reprogram. 2017 Oct;19(5):289-293. doi: 10.1089/cell.2017.0015. Epub 2017 Aug 28.
MicroRNAs (miRNAs) with 20-30 nucleotides have recently emerged as the multidimensional regulators of cell fate decisions. Recent improvement in high-throughput sequencing has highlighted the potential role of LIN28/let-7 regulatory network in several developmental events. It was proposed that this pathway might represent a functional signature in cell proliferation, transition between commitment and pluripotency, and regulation of cancer and tumorigenicity. LIN28/let-7 regulatory pathway is one of the excellent examples of the relationship between an miRNA and mRNAs. This review article highlights the potentials of LIN28/let-7 signaling in gene regulatory pathways during pluripotency, reprogramming, and tumorigenicity.
长度为20 - 30个核苷酸的微小RNA（miRNA）最近已成为细胞命运决定的多维度调节因子。高通量测序技术的最新进展突出了LIN28/let-7调控网络在多个发育事件中的潜在作用。有人提出，该通路可能代表细胞增殖、定向分化与多能性转变以及癌症和肿瘤发生调控中的一种功能特征。LIN28/let-7调控通路是miRNA与mRNA之间关系的典型例子之一。这篇综述文章重点介绍了LIN28/let-7信号在多能性、重编程和肿瘤发生过程中的基因调控通路中的潜力。
