淋巴管生成：分子机制与未来前景。

Lymphangiogenesis: Molecular mechanisms and future promise.

机构信息

Molecular/Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland.

出版信息

Cell. 2010 Feb 19;140(4):460-76. doi: 10.1016/j.cell.2010.01.045.

DOI:10.1016/j.cell.2010.01.045

PMID:20178740

Abstract

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.

摘要

淋巴管的生长（淋巴管生成）积极参与了许多病理过程，包括组织炎症和肿瘤扩散，但在患有淋巴水肿的患者中是不足的，淋巴水肿是一种以慢性组织水肿和免疫功能受损为特征的衰弱性疾病。最近对控制淋巴管生成的分子机制的知识的大量增加为治疗这些疾病提供了新的可能性。