Department of Internal Medicine, Division of Rheumatology, Clinical Immunology and Allergy, University of Crete Medical School, 1 Voutes Street, 71110 Heraklion, Greece.
Lupus. 2010 May;19(6):744-7. doi: 10.1177/0961203309358601. Epub 2010 Feb 23.
Cutaneous lupus erythematosus includes a variety of lupus erythematosus specific skin lesions that, in some cases, can be disfiguring and refractory to conventional therapy. This short report describes our experience in treating six patients with severe, refractory subacute cutaneous lupus erythematosus with monthly cyclophosphamide pulses, followed by azathioprine as maintenance therapy. Significant clinical improvement of the subacute cutaneous lupus erythematosus lesions was achieved in all patients, with four patients in complete remission and two in partial remission. Mean time to clinical response was 4.33 +/- 1.36 months. Minor adverse events and no relapses were noted in a follow-up period of more than 3 years.
皮肤狼疮包括多种狼疮特异性皮肤损伤，在某些情况下，这些损伤可能会导致毁容和对抗生素治疗无效。本短篇报告描述了我们采用每月环磷酰胺冲击治疗，随后用硫唑嘌呤维持治疗的方法，治疗 6 例严重、难治性亚急性皮肤型狼疮的经验。所有患者的亚急性皮肤型狼疮损伤均显著改善，4 例患者完全缓解，2 例患者部分缓解。达到临床缓解的平均时间为 4.33 +/- 1.36 个月。在超过 3 年的随访期间，仅观察到轻微不良反应，无疾病复发。
