Department of Dermatology, Cleveland Clinic, 9500 Euclid Avenue, A-61, Cleveland, OH 44195, USA.
Dermatol Clin. 2010 Jul;28(3):489-99. doi: 10.1016/j.det.2010.03.007.
This article focuses on the management of discoid lupus erythematosus, subacute cutaneous lupus erythematosus, and systemic lupus erythematosus when the usual therapeutic arsenal such as oral antimalarial drugs and topical/oral steroids fail or provide insufficient treatment efficacy. Many of the treatments listed are the same or similar to each other because of similarities in the pathogenesis of various subtypes of cutaneous lupus. The clinical challenge is to determine the indications for topical versus systemic therapy, and to also identify the scenarios when combined therapy is necessary.
本文重点介绍盘状红斑狼疮、亚急性皮肤型红斑狼疮和全身性红斑狼疮的治疗管理，当常规治疗方法（如口服抗疟药物和局部/口服类固醇）无效或疗效不足时。列出的许多治疗方法彼此相似，因为各种皮肤型红斑狼疮的发病机制相似。临床挑战在于确定局部治疗与系统治疗的适应证，以及确定何时需要联合治疗。
