Department of Radiation Oncology, Cleveland Clinic, 9500 Euclid Avenue, T28, Cleveland, OH 44195, USA.
Cleve Clin J Med. 2010 Mar;77 Suppl 1:S27-9. doi: 10.3949/ccjm.77.s1.06.
Radiation therapy is recommended as an adjuvant to resection for intermediate- and high-grade soft-tissue sarcomas; its role in bone sarcomas is largely limited to select patients with Ewing sarcoma. Despite the integral role of radiation therapy in soft-tissue sarcoma management, its optimal timing--preoperative versus postoperative--is uncertain, with each timing scenario having advantages and disadvantages. Preparation for radiation therapy involves a detailed planning session to optimize and standardize patient positioning and determine the target volume. Side effects of radiation therapy may include skin changes, delayed wound healing and other wound complications, fatigue, reduced range of motion of the affected limb, pain, and bone fractures.
放射治疗被推荐作为中高级软组织肉瘤切除术的辅助治疗手段；在骨肉瘤中的作用主要限于选择的尤文肉瘤患者。尽管放射治疗在软组织肉瘤的治疗中具有重要作用，但术前与术后的最佳时机不确定，每种时机方案都有其优缺点。放射治疗的准备包括详细的规划会议，以优化和标准化患者的定位，并确定目标体积。放射治疗的副作用可能包括皮肤变化、延迟伤口愈合和其他伤口并发症、疲劳、受累肢体活动范围减少、疼痛和骨折。
