Thoracic Disease Research Unit, Division of Pulmonary & Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Cell Adh Migr. 2010 Apr-Jun;4(2):194-8. doi: 10.4161/cam.4.2.10900. Epub 2010 Apr 8.
Integrins are transmembrane heterodimeric receptors responsible for transducing and modulating signals between the extracellular matrix and cytoskeleton, ultimately influencing cell functions such as adhesion and migration. Integrin alpha9beta1 is classified within a two member sub-family of integrins highlighted in part by its specialized role in cell migration. The importance of this role is demonstrated by its regulation of numerous biological functions including lymphatic valve morphogenesis, lymphangiogenesis, angiogenesis and hematopoietic homeostasis. Compared to other integrins the signaling mechanisms that transduce alpha9beta1-induced cell migration are not well described. We have recently shown that Src tyrosine kinase plays a key proximal role to control alpha9beta1 signaling. Specifically it activates inducible nitric oxide synthase (iNOS) and in turn nitric oxide (NO) production as a means to transduce cell migration. Furthermore, we have also described a role for FAK, Erk and Rac1 in alpha9beta1 signal transduction. Here we provide an over view of known integrin alpha9beta1 signaling pathways and highlight its roles in diverse biological conditions.
整合素是跨膜异二聚体受体，负责在细胞外基质和细胞骨架之间传递和调节信号，最终影响细胞的黏附和迁移等功能。整合素 α9β1 属于整合素的两个亚家族成员之一，其在细胞迁移中的特殊作用是其特征之一。该作用的重要性体现在其对多种生物学功能的调节，包括淋巴脉管瓣膜发生、淋巴管生成、血管生成和造血稳态。与其他整合素相比，传递 α9β1 诱导的细胞迁移的信号机制尚未得到很好的描述。我们最近表明，Src 酪氨酸激酶在控制 α9β1 信号中起着关键的近端作用。具体来说，它激活诱导型一氧化氮合酶（iNOS），进而产生一氧化氮（NO）作为传递细胞迁移的一种手段。此外，我们还描述了 FAK、Erk 和 Rac1 在 α9β1 信号转导中的作用。本文概述了已知的整合素 α9β1 信号通路，并强调了其在多种生物学条件下的作用。
