Department of Dermatology, Hopital Saint-Louis, Paris, France.
Adv Anat Pathol. 2010 Mar;17(2):73-90. doi: 10.1097/PAP.0b013e3181cfe758.
The following communication summarizes the proceedings of a one-day International Workshop focusing on the histology of benign melanocytic nevi. Areas of controversy identified in 6 focus sessions were the nomenclature and relationships among common nevi including nevi with halo reactions, traumatized nevi, "dysplastic" nevi, and nevi from particular anatomic sites; developmental biology and frequency of malignant transformation associated with congenital nevi; the characterization and biologic nature of atypical spitzoid neoplasms; the basic definition of particular melanocytic cellular phenotypes, and the nomenclature and biologic nature of many candidate blue nevi, combined nevi, and other controversial lesions such as deep penetrating nevus and pigmented epithelioid melanocytoma. Concentrated data collection and follow-up, molecular characterization, and future consensus Workshops may facilitate the resolution of some of these problems. The Group recommended the description of ambiguous or "borderline" lesions as tumors with indeterminate or uncertain biologic/malignant potential. The participants also advised that such lesions at a minimum should be managed by complete excision with clear surgical margins.
以下通讯总结了为期一天的国际研讨会的会议记录，该研讨会重点关注良性黑色素细胞痣的组织学。在 6 个重点会议中确定了有争议的领域，包括常见痣（包括有晕反应的痣、创伤性痣、“发育不良”痣和特定解剖部位的痣）的命名和关系；与先天性痣相关的恶性转化的发育生物学和频率；非典型 Spitz 样肿瘤的特征和生物学性质；特定黑色素细胞表型的基本定义，以及许多候选蓝色痣、联合痣和其他有争议病变（如深层穿透痣和色素性上皮样黑素细胞瘤）的命名和生物学性质。集中的数据收集和随访、分子特征描述以及未来的共识研讨会可能有助于解决其中的一些问题。专家组建议将模棱两可或“边界”病变描述为具有不确定或不确定的生物学/恶性潜能的肿瘤。与会者还建议，此类病变至少应通过完全切除并具有明确的手术切缘来进行管理。
