School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.
Chem Soc Rev. 2010 Mar;39(3):1133-52. doi: 10.1039/b820266b. Epub 2010 Jan 12.
Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).
具有纳米尺度的流体制备系统可以实现对 DNA 分子的灵敏分析。利用纳流体制备系统可以探测 DNA 分子的构象、动态和熵特性，基于 DNA 分子与限制环境的长度依赖相互作用快速对 DNA 分子进行分类，以及确定长 DNA 分子上遗传信息的空间位置。在这篇评论中，我们回顾了最近利用纳米通道、纳米狭缝、纳米孔和零模波导等流体制备系统进行 DNA 分析的实验（161 篇参考文献）。
