Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy.
Anal Bioanal Chem. 2010 Apr;396(7):2543-6. doi: 10.1007/s00216-010-3537-7. Epub 2010 Feb 24.
Lithium salts are still one of the most popular therapeutic approaches to the treatment of bipolar disorders, notwithstanding the introduction of more modern, less toxic drugs. Because of a narrow therapeutic range, lithium serum concentrations must be strictly monitored during the treatment to avoid life-threatening neurotoxicity. For this purpose, methods based on flame photometry or ion-selective electrodes are usually applied. The aim of the present work was to develop and validate a simple method for the determination of lithium in serum based on capillary zone electrophoresis with indirect detection. A validation of the method was carried out, including a comparison with an automated routine method based on ion-selective electrodes.
尽管已经引入了更现代、毒性更低的药物，但锂盐仍然是治疗双相情感障碍最常用的治疗方法之一。由于治疗范围较窄，因此在治疗过程中必须严格监测锂血清浓度，以避免危及生命的神经毒性。为此，通常应用基于火焰光度法或离子选择性电极的方法。本工作的目的是开发和验证一种基于间接检测的毛细管区带电泳法测定血清中锂的简单方法。对该方法进行了验证，包括与基于离子选择性电极的自动化常规方法进行比较。
