Schmitz-Dräger B J, Bismarck E, Lümmen G
Urologie, EuromedClinic, Europa-Allee 1, 90763 Fürth.
Urologe A. 2010 Feb;49(2):233-7. doi: 10.1007/s00120-010-2240-9.
Acceptance of prostate cancer as an endemic disease was the basis for the decision reached by the guideline committee to devote a chapter to the topic of risks and prevention of prostate cancer. Analysis of the substantial data regarding these subjects, however, shows that a number of apparently accepted risk factors and recommendations for prevention do not withstand subtle assessment. For this reason, only information concerning the risk factors of age and genetic predisposition is obtained from men. While the role of nutrition in the pathogenesis of prostate cancer remains beyond dispute, data on individual food items are very contradictory. Positive results of interventional studies are not available. Thus, the committee issued general recommendations on nutrition and lifestyle which also include other malignant tumors and the risk for cardiovascular disease. New findings of prospective studies on chemoprevention were incorporated into a statement. Since 5-alpha-reductase inhibitors have not yet been approved for prevention of prostate cancer, no recommendation was given.
将前列腺癌视为一种地方病是指南委员会决定专门用一章来讨论前列腺癌风险与预防这一主题的依据。然而，对有关这些主题的大量数据进行分析后发现，一些看似公认的风险因素和预防建议经不起细致评估。因此，仅从男性那里获取了有关年龄和遗传易感性等风险因素的信息。虽然营养在前列腺癌发病机制中的作用无可争议，但关于个别食物的数据却非常矛盾。干预性研究尚无阳性结果。因此，委员会发布了关于营养和生活方式的一般性建议，这些建议也适用于其他恶性肿瘤和心血管疾病风险。前瞻性化学预防研究的新发现被纳入了一份声明中。由于5-α还原酶抑制剂尚未被批准用于预防前列腺癌，所以未给出相关建议。
