Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan.
World J Gastroenterol. 2010 Feb 28;16(8):987-91. doi: 10.3748/wjg.v16.i8.987.
To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possible relationship with gastro-esophageal reflux disease.
Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine, losartan, and atenolol, as well as without any drug administration.
Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were significantly higher than those without medication in a supine position. On the other hand, peristaltic pressures under nifedipine administration were lower than those observed without drug administration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition, while the effects of nifedipine were the opposite.
Among the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine.
阐明抗高血压药物对食管收缩的影响，并确定其与胃食管反流病的可能关系。
纳入 13 名健康男性志愿者。使用高分辨率测压法测量食管体蠕动收缩和食管下括约肌（LES）压力。所有受试者在 4 次单独检查中随机接受硝苯地平、氯沙坦和阿替洛尔治疗，以及不服用任何药物。
食管体蠕动收缩被两个波谷分为三个节段。阿替洛尔给药时食管体中下段蠕动收缩的峰值压力在仰卧位时明显高于不服用药物时。另一方面，硝苯地平给药时的蠕动压力低于未用药时。氯沙坦不改变食管体蠕动。阿替洛尔升高 LES 压力并减缓蠕动波转换，而硝苯地平的作用则相反。
在所测试的抗高血压药物中，阿替洛尔增强了食管运动活动，与硝苯地平相反。
