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机器人辅助远端输尿管切除术联合Boari皮瓣重建术治疗远端输尿管尿路上皮癌:单中心初步经验

Robotic distal ureterectomy with boari flap reconstruction for distal ureteral urothelial cancers: a single institutional pilot experience.

作者信息

Allaparthi Satya, Ramanathan Rajan, Balaji K C

机构信息

Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester 01655, MA, USA.

出版信息

J Laparoendosc Adv Surg Tech A. 2010 Mar;20(2):165-71. doi: 10.1089/lap.2009.0269.

Abstract

OBJECTIVE

Low-grade urothelial tumors of the distal ureter historically can be managed by open distal ureterectomy and ureteral reimplantation with or without bladder reconstruction. In recent years, the da Vinci surgical robotic system (DSRS) (Intuitive Surgical Inc., Sunnyvale, CA) has being increasingly used to perform complex urologic cancer surgeries. In this article, we report first on two consecutive patients undergoing robotic distal ureterectomy and Boari flap reconstruction (RDUBF) for distal ureteral cancer.

PATIENTS AND METHODS

Two consecutive patients underwent RDUBF, both with a diagnosis of low-grade papillary neoplasm of a distal ureter at our institution between August 2008 and November 2008. Perioperative parameters were prospectively collected and analyzed following institutional review board approval.

RESULTS

Two patients, male and female (age, 70 and 71 years, respectively) were included in the study. In both the patients, RDUBF was completed transperitoneally without the need for open conversion. The operative time, estimated blood loss, time to hospital discharge, and time to stent removal for both patients were 270 and 220 minutes, 25 and 35 mL, and 2 days and 6 weeks, respectively. The percentage change in hematocrit following surgery was within 5% in all patients. There were no postoperative complications in both patients. Final pathology demonstrated low-grade carcinoma pT1NxMx and pTaNxMx papillary urothelial carcinoma with negative margins in both patients. A MAG3 (mercapto-acetyl-tri-glycine) renal scan at 3 months demonstrated prompt drainage in both patients. At a median follow-up of 6 months, the patients were alive with no signs of recurrent or metastatic disease on cystoscopic, cytologic, or radiologic follow-up.

CONCLUSIONS

RDUBF reconstruction is technically feasible with using DSRS in select patients with distal ureteral cancer without disease recurrence in the short term. A larger cohort, with long-term follow-up, is necessary to validate our results.

摘要

目的

以往,远端输尿管的低级别尿路上皮肿瘤可通过开放性远端输尿管切除术和输尿管再植术进行治疗,可选择或不进行膀胱重建。近年来,达芬奇手术机器人系统(DSRS,直观外科公司,加利福尼亚州桑尼维尔)越来越多地用于进行复杂的泌尿外科癌症手术。在本文中,我们首次报告了两名连续接受机器人辅助远端输尿管切除术及Boari皮瓣重建术(RDUBF)治疗远端输尿管癌的患者。

患者与方法

2008年8月至2008年11月期间,两名连续患者在我们机构接受了RDUBF手术,二者均被诊断为远端输尿管低级别乳头状肿瘤。在获得机构审查委员会批准后,前瞻性收集并分析围手术期参数。

结果

两名患者,一男一女(年龄分别为70岁和71岁)纳入本研究。两名患者均经腹腔完成RDUBF手术,无需转为开放手术。两名患者的手术时间、估计失血量、出院时间及拔管时间分别为270分钟和220分钟、25毫升和35毫升、2天和6周。所有患者术后血细胞比容变化百分比均在5%以内。两名患者均未出现术后并发症。最终病理显示两名患者均为低级别癌,pT1NxMx及pTaNxMx乳头状尿路上皮癌,切缘阴性。术后3个月的MAG3(巯基乙酰三甘氨酸)肾扫描显示两名患者均引流顺畅。中位随访6个月时,经膀胱镜检查、细胞学检查或影像学随访,两名患者均存活,无复发或转移疾病迹象。

结论

对于部分远端输尿管癌患者,使用DSRS进行RDUBF重建在技术上是可行的,且短期内无疾病复发。需要更大规模的队列研究及长期随访来验证我们的结果。

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