University of Southern California, Preventive Medicine, Alhambra, California 91803, USA.
Am J Drug Alcohol Abuse. 2009;35(4):209-13. doi: 10.1080/00952990903005940.
Discussed are potential roles for neurocognitive function in models of substance misuse prevention. Regional heterogeneity in the time-course of brain development appears to be one contributor to adolescent substance misuse vulnerability as areas of the brain related to reward, pleasure, novelty seeking, and emotion achieve functional maturity much earlier in development than do frontal-cortical areas of the brain responsible for self-regulation of behavior and higher order cognitive decision-making. We review the literature related to the development of neurocognitive systems known to correlate with substance misuse and suggest roles for neurocognition in models of substance misuse prevention outcomes. Implications and future directions for neurocognitive models of substance misuse prevention are also discussed.
探讨了神经认知功能在物质滥用预防模型中的潜在作用。大脑发育过程中的区域异质性似乎是青少年物质滥用易感性的一个因素，因为与奖励、愉悦、寻求新奇和情绪相关的大脑区域在发育过程中比负责行为自我调节和更高阶认知决策的额叶皮质区域更早达到功能成熟。我们回顾了与与物质滥用相关的神经认知系统的发展相关的文献，并提出了神经认知在物质滥用预防结果模型中的作用。还讨论了物质滥用预防的神经认知模型的意义和未来方向。
