Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China.
Behav Brain Funct. 2010 Jan 22;6:7. doi: 10.1186/1744-9081-6-7.
Vitamin A and its derivatives (retinoids) are crucial for the development, maintenance and morphogenesis of the central nervous system (CNS). Although motor impairment has been reported in postnatal vitamin A depletion rodents, the effect of vitamin A depletion on homeostasis maintaining capability in response to external interference is not clear.
In the current study, we measured the effect of vitamin A depletion on motor ability and pain sensitivity under two different conditions: 1. prior to any injection and 2. after the injection of an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801).
Vitamin A depletion mice showed decreased body weight, enhanced locomotor activity, increased rearing and less tail flick latency. Vitamin A depletion also induced hypersensitivity of stereotypy, ataxia, rearing, and tail flick latency to MK-801, but hyposensitivity of locomotion to MK-801.
These findings suggest that vitamin A depletion affect broad basal behavior and disrupt homeostasis maintaining capability in response to glutamate perturbation. We provide a useful animal model for assessing the role of vitamin A depletion in regulating animal behavior, and for detecting how neurotransmitter pathways might be involved in vitamin A depletion related behavioral abnormalities.
维生素 A 及其衍生物（视黄醇）对于中枢神经系统（CNS）的发育、维持和形态发生至关重要。尽管已经报道了产后维生素 A 耗竭的啮齿动物存在运动障碍，但维生素 A 耗竭对维持应对外部干扰的能力的影响尚不清楚。
在本研究中，我们测量了维生素 A 耗竭对两种不同条件下运动能力和疼痛敏感性的影响：1. 在任何注射之前；2. 在注射 N-甲基-D-天冬氨酸（NMDA）受体拮抗剂（MK-801）之后。
维生素 A 耗竭小鼠的体重下降，运动活性增强，后肢抬起和尾巴摆动潜伏期减少。维生素 A 耗竭还导致刻板行为、共济失调、后肢抬起和尾巴摆动潜伏期对 MK-801的敏感性增加，但对 MK-801的运动敏感性降低。
这些发现表明，维生素 A 耗竭会影响广泛的基础行为，并破坏对谷氨酸扰动的维持平衡能力。我们提供了一个有用的动物模型，用于评估维生素 A 耗竭在调节动物行为中的作用，并检测神经递质途径如何参与与维生素 A 耗竭相关的行为异常。
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