C57BL/6小鼠对MK-801诱导的运动和刻板行为的年龄相关差异敏感性。
Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice.
作者信息
Qi Chunting, Zou Hong, Zhang Ruizhong, Zhao Guoping, Jin Meilei, Yu Lei
机构信息
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China.
出版信息
Eur J Pharmacol. 2008 Feb 2;580(1-2):161-8. doi: 10.1016/j.ejphar.2007.07.071. Epub 2007 Nov 12.
Abstract
Psychomotor effects elicited by systemic administration of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) represent perturbation of glutamatergic pathways, providing an animal model for psychotic symptoms of schizophrenia. Hyperlocomotion and stereotypy are the two main psychomotor behaviors induced by MK-801. This study compared MK-801-induced hyperlocomotion and stereotypy in young (1-month old) and aged mice (12-month old), in order to determine how the aging process may influence these behaviors. The tested MK-801 doses ranged from 0.015 to 1 mg/kg. The data indicated that MK-801 impacted the aged mice more pronouncedly than the young mice, as both hyperlocomotion and stereotypy were increased significantly more in the aged mice relative to the young mice. These results suggest an age-related increase in MK-801 sensitivity in mice.
摘要
通过全身给予非竞争性NMDA（N-甲基-D-天冬氨酸）受体拮抗剂MK-801（马来酸氯氮平）所引发的精神运动效应代表了谷氨酸能通路的紊乱，为精神分裂症的精神病症状提供了一种动物模型。活动亢进和刻板行为是由MK-801诱导的两种主要精神运动行为。本研究比较了MK-801在年轻（1个月大）和老年小鼠（12个月大）中诱导的活动亢进和刻板行为，以确定衰老过程如何影响这些行为。所测试的MK-801剂量范围为0.015至1mg/kg。数据表明，MK-801对老年小鼠的影响比对年轻小鼠更明显，因为相对于年轻小鼠，老年小鼠的活动亢进和刻板行为均显著增加。这些结果表明小鼠对MK-801的敏感性与年龄相关增加。
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