Department of Pathology, Wayne State University, Sinai Grace Hospital/Detroit Medical Center, Detroit, Michigan, USA.
Diagn Pathol. 2010 Jan 26;5:9. doi: 10.1186/1746-1596-5-9.
Thyroid nodules are common among adults though only a small percentage is malignant, which can histologically mimic benign nodules. Accurate diagnosis of these thyroid nodules is critical for the proper clinical management.
We investigated immunoexpression in 98 surgically removed benign thyroid nodules including 52 hyperplastic nodules (HN) and 46 follicular/Hurthle cell adenomas (FA), and 54 malignant tumors including 22 follicular carcinoma (FC), 20 classic papillary carcinoma (PTC), and 12 follicular variant papillary carcinoma (FVPC).
The staining results showed that malignant tumors express galectin-3, HBME-1, CK19 and Ret oncoprotein significantly more than benign nodules. The sensitivity of these markers for the distinction between benign and malignant lesions ranged from 83.3% to 87%. The sensitivity of two-marker panels was not significantly different. Immunoexpression was usually diffuse and strong in malignant tumors, and focal and weak in the benign lesions.
Our findings indicate that these immunomarkers are significantly more expressed in malignant tumors compared to benign lesions and may be of additional diagnostic value when combined with routine histology.
甲状腺结节在成年人中很常见，尽管只有一小部分是恶性的，但它们在组织学上可以模拟良性结节。准确诊断这些甲状腺结节对于正确的临床管理至关重要。
我们研究了 98 个手术切除的良性甲状腺结节的免疫表达，包括 52 个增生性结节（HN）和 46 个滤泡/ Hurthle 细胞腺瘤（FA），以及 54 个恶性肿瘤，包括 22 个滤泡癌（FC）、20 个经典乳头状癌（PTC）和 12 个滤泡状变体乳头状癌（FVPC）。
染色结果表明，恶性肿瘤的 galectin-3、HBME-1、CK19 和 Ret 癌基因蛋白表达明显高于良性结节。这些标志物用于区分良恶性病变的敏感性在 83.3%到 87%之间。两个标志物组合的敏感性没有显著差异。免疫表达在恶性肿瘤中通常是弥漫性和强阳性，而在良性病变中则是局灶性和弱阳性。
我们的研究结果表明，与良性病变相比，这些免疫标志物在恶性肿瘤中表达明显更高，当与常规组织学结合使用时，可能具有额外的诊断价值。
