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1
Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis.趋化因子受体对单核细胞亚群迁移和存活的调节及其与动脉粥样硬化的相关性。
Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1412-8. doi: 10.1161/ATVBAHA.108.180505.
2
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.单核细胞亚群以不同方式利用CCR2、CCR5和CX3CR1在动脉粥样硬化斑块内聚集。
J Clin Invest. 2007 Jan;117(1):185-94. doi: 10.1172/JCI28549.
3
High-throughput genotyping with energy transfer-labeled primers.使用能量转移标记引物进行高通量基因分型。
Methods Mol Biol. 2006;335:215-40. doi: 10.1385/1-59745-069-3:215.
4
Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease.趋化因子配体和受体的多态性对冠状动脉疾病易感性的影响。
Thromb Res. 2007;119(1):63-71. doi: 10.1016/j.thromres.2005.12.016. Epub 2006 Feb 9.
5
Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic population.
Atherosclerosis. 2006 Oct;188(2):341-6. doi: 10.1016/j.atherosclerosis.2005.11.014. Epub 2005 Dec 13.
6
On the interpretation of genetic association studies.
Eur Heart J. 2004 Aug;25(16):1378-81. doi: 10.1016/j.ehj.2004.06.035.
7
The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics.趋化因子在动脉粥样硬化中的作用：来自实验模型和群体遗传学的最新证据。
Curr Opin Lipidol. 2004 Apr;15(2):145-9. doi: 10.1097/00041433-200404000-00007.
8
Genetic factors in cardiovascular disease. 10 questions.心血管疾病中的遗传因素。10个问题。
Trends Cardiovasc Med. 2003 Nov;13(8):309-16. doi: 10.1016/j.tcm.2003.08.001.
9
Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age.
J Mol Med (Berl). 2003 Jun;81(6):363-7. doi: 10.1007/s00109-003-0435-x. Epub 2003 Apr 29.
10
Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis.将单核细胞CC趋化因子受体2缺陷型骨髓移植到载脂蛋白E3-莱顿小鼠体内可抑制动脉粥样硬化的形成。
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):447-53. doi: 10.1161/01.ATV.0000058431.78833.F5. Epub 2003 Jan 30.

CCR2与冠状动脉疾病：西苏格兰冠心病预防研究的一项子研究

CCR2 and coronary artery disease: a woscops substudy.

作者信息

Dow David J, McMahon Alex D, Gray Ian C, Packard Chris J, Groot Pieter He

机构信息

GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK.

出版信息

BMC Res Notes. 2010 Feb 2;3:31. doi: 10.1186/1756-0500-3-31.

DOI:10.1186/1756-0500-3-31
PMID:20181074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2829582/
Abstract

BACKGROUND

Several lines of evidence support a role for CCL2 (monocyte chemotactic protein-1) and its receptor CCR2 in the development of atherosclerosis. The aim of the present study was to determine the association of the CCR2 Val64Ile polymorphism with the development of coronary artery disease in the WOSCOPS study sample set.

FINDINGS

A total of 443 cases and 1003 controls from the West of Scotland Coronary Prevention Study (WOSCOPS) were genotyped for the Val64Ile polymorphism in the CCR2 gene. Genotype frequencies were compared between cases and controls. The CCR2 Val64Ile polymorphism was found not to be associated with coronary events in this study population (odds ratio 1.15, 95% CI 0.82-1.61, p = 0.41).

CONCLUSIONS

This case-control study does not support an association of the CCR2 Val64Ile polymorphism with coronary artery disease in the WOSCOPS sample set and does not confirm a possible protective role for CCR2 Val64Ile in the development of coronary artery disease.

摘要

背景

多项证据支持CCL2（单核细胞趋化蛋白-1）及其受体CCR2在动脉粥样硬化发展过程中发挥作用。本研究的目的是在西苏格兰冠心病预防研究（WOSCOPS）样本集中确定CCR2基因Val64Ile多态性与冠心病发展之间的关联。

研究结果

对来自西苏格兰冠心病预防研究（WOSCOPS）的443例病例和1003例对照进行CCR2基因Val64Ile多态性基因分型。比较病例组和对照组的基因型频率。在该研究人群中，发现CCR2 Val64Ile多态性与冠心病事件无关（比值比1.15，95%可信区间0.82 - 1.61，p = 0.41）。

结论

这项病例对照研究不支持在WOSCOPS样本集中CCR2 Val64Ile多态性与冠心病有关联，也未证实CCR2 Val64Ile在冠心病发展过程中可能具有的保护作用。