Benomar Sophia, Boutayeb Saber, Benzekri Leila, Errihani Hassan, Hassam Badreddine
Department of Dermatology, Ibn Sina Hospital, Rabat, Morocco.
Cases J. 2009 Sep 17;2:7092. doi: 10.1186/1757-1626-0002-0000007092.
Kaposi's sarcoma, a virus-associated neoplasm, can be treated with systemic therapy such interferon or chemotherapy, although a local alternative is possible in localized disease.Topical imiquimod is a ligand of the toll-like receptors 7 and 8 on dendritic cells, increasing immune responses and showing antiviral and antitumoral activities. We report a spectacular response to imiquimod 5% cream in a patient with classic Kaposi's sarcoma of the leg.
卡波西肉瘤是一种与病毒相关的肿瘤,可采用全身治疗,如干扰素或化疗,不过对于局限性疾病也有局部治疗的选择。外用咪喹莫特是树突状细胞上Toll样受体7和8的配体,可增强免疫反应并具有抗病毒和抗肿瘤活性。我们报告了一名腿部经典型卡波西肉瘤患者对5%咪喹莫特乳膏有显著反应。