Morand J J, Lightburn E, Simon F, Patte J H
Service de dermatologie Médecin, HIA Laveran, Marseille, France.
Med Trop (Mars). 2007 Apr;67(2):123-30.
Kaposi's sarcoma (KS) is a mesenchymal tumor involving blood and lymphatic vessels and induced by viral growth factors (HHV8-IL6). This article reviews the epidemiology, pathogenesis, clinical spectrum (classic KS, iatrogenic immunosuppressive KS, endemic African KS, and AIDS-KS), histological features, staging criteria and treatment of KS. Unlike industrialized countries that have benefited from widespread use of highly active antiretroviral therapy (HAART), developing countries continue to have a high incidence of AIDS-KS. Future therapeutic targets for KS are enhancement of immune function and treatment with angiogenesis inhibitors
卡波西肉瘤（KS）是一种涉及血液和淋巴管的间充质肿瘤，由病毒生长因子（HHV8-IL6）诱导。本文综述了卡波西肉瘤的流行病学、发病机制、临床谱（经典型KS、医源性免疫抑制性KS、地方性非洲KS和艾滋病相关性KS）、组织学特征、分期标准及治疗。与受益于高效抗逆转录病毒疗法（HAART）广泛应用的工业化国家不同，发展中国家的艾滋病相关性KS发病率仍然很高。卡波西肉瘤未来的治疗靶点是增强免疫功能以及使用血管生成抑制剂进行治疗。
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