ETH Zurich, Automatic Control Laboratory, Physikstrasse 3, 8092 Zurich, Switzerland.
J Chromatogr A. 2010 Mar 26;1217(13):2013-21. doi: 10.1016/j.chroma.2010.01.074. Epub 2010 Feb 1.
In order to better exploit the economic potential of the simulated moving bed chromatography a 'cycle to cycle' controller which only requires the information about the linear adsorption behavior and the overall average porosity of the columns has been proposed. Recently, an automated on-line HPLC monitoring system which determines the concentrations in the two product streams averaged over one cycle, and returns them as feedback information to the controller was implemented. The new system allows for an accurate determination of the average concentration of the product streams even if the plant is operated at high concentrations. This paper presents the experimental implementation of the 'cycle to cycle' control concept to the separation of guaifenesin enantiomers under nonlinear chromatographic conditions, i.e. at high feed concentrations. Different case studies have been carried out to challenge the controller under realistic operation conditions, e.g. introducing pump disturbances and changing the feed concentration during the operation. The experimental results clearly demonstrate that the controller can indeed deliver the specified purities and improve the process performance.
为了更好地开发模拟移动床色谱的经济潜力，提出了一种仅需要线性吸附行为信息和柱体总体平均孔隙率的“循环到循环”控制器。最近，实现了一种自动化在线 HPLC 监测系统，该系统可在一个周期内平均测定两个产品流中的浓度，并将其作为反馈信息返回给控制器。即使在高浓度下操作，该新系统也允许准确地确定产品流的平均浓度。本文将“循环到循环”控制概念的实验实施应用于非线性色谱条件下（即在高进料浓度下）分离愈创木酚对映异构体。进行了不同的案例研究，以在实际操作条件下对控制器进行挑战，例如在操作过程中引入泵干扰和改变进料浓度。实验结果清楚地表明，控制器确实可以提供指定的纯度并提高工艺性能。
