Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
J Chromatogr A. 2011 Dec 30;1218(52):9345-52. doi: 10.1016/j.chroma.2011.10.073. Epub 2011 Nov 3.
One of the modified simulated moving bed (SMB) processes, the intermittent SMB (I-SMB) process, has been recently analyzed theoretically [1] and its superior performance compared to the conventional SMB process has been demonstrated at a rather low total feed concentration through experiments and simulations [2]. This work shows that the I-SMB process outperforms the conventional SMB process also at high feed concentration where the species are clearly subject to a nonlinear adsorption isotherm. In the case of the separation of the Tröger's base's enantiomers in ethanol on ChiralPak AD, the two processes operated in a six-column 1-2-2-1 configuration (one column in sections 1 and 4 and two columns in sections 2 and 3) and in a four-column 1-1-1-1 configuration (one column in each section) are compared at high feed concentration through both experiments and simulations. Even under nonlinear conditions the four column I-SMB process can successfully separate the two enantiomers achieving purity levels as high as the two six column processes and exhibiting better productivity.
最近，人们对一种改良的模拟移动床（SMB）工艺，即间歇式 SMB（I-SMB）工艺，进行了理论分析[1]，并通过实验和模拟证明，与传统 SMB 工艺相比，该工艺在较低的总进料浓度下表现出优异的性能[2]。这项工作表明，即使在进料浓度较高、各物质明显受到非线性吸附等温线影响的情况下，I-SMB 工艺的性能仍优于传统 SMB 工艺。在以 ChiralPak AD 为固定相、乙醇为洗脱剂拆分 Tröger's 碱对映异构体的过程中，对在高进料浓度下采用六柱 1-2-2-1（第 1 和第 4 节各一个柱，第 2 和第 3 节各两个柱）和四柱 1-1-1-1（每个节一个柱）两种构型的 I-SMB 工艺进行了实验和模拟比较。即使在非线性条件下，四柱 I-SMB 工艺也能成功分离两种对映异构体，达到与两种六柱工艺相当的纯度水平，且表现出更好的生产效率。
