Department of Medicine, Center for Health Disparities Research, Medical University of South Carolina, Charleston, SC, United States.
Diabetes Res Clin Pract. 2010 Mar;87(3):302-12. doi: 10.1016/j.diabres.2010.01.024. Epub 2010 Feb 23.
Diabetes and depression are highly prevalent conditions and have significant impact on health outcomes. This study reviewed the literature on the prevalence, burden of illness, morbidity, mortality, and cost of comorbid depression in people with diabetes as well as the evidence on effective treatments.
Systematic review of the literature on the relationship between diabetes and depression was performed. A comprehensive search of the literature was performed on Medline from 1966 to 2009. Studies that examined the association between diabetes and depression were reviewed. A formal meta-analysis was not performed because of the broad area covered and the heterogeneity of the studies. Instead, a qualitative aggregation of studies was performed.
Diabetes and depression are debilitating conditions that are associated with significant morbidity, mortality, and healthcare costs. Coexisting depression in people with diabetes is associated with decreased adherence to treatment, poor metabolic control, higher complication rates, decreased quality of life, increased healthcare use and cost, increased disability and lost productivity, and increased risk of death.
The coexistence of diabetes and depression is associated with significant morbidity, mortality, and increased healthcare cost. Coordinated strategies for clinical care are necessary to improve clinical outcomes and reduce the burden of illness.
糖尿病和抑郁症是高患病率的疾病，对健康结果有重大影响。本研究回顾了关于糖尿病患者并发抑郁症的患病率、疾病负担、发病率、死亡率和成本，以及有效治疗方法的证据。
对糖尿病和抑郁症之间关系的文献进行系统回顾。对 1966 年至 2009 年期间的 Medline 文献进行全面检索。综述了检查糖尿病与抑郁症之间关联的研究。由于研究范围广泛且存在异质性，因此未进行正式的荟萃分析。而是对研究进行了定性综合。
糖尿病和抑郁症是使人虚弱的疾病，与严重的发病率、死亡率和医疗保健费用有关。患有糖尿病的患者并发抑郁症与治疗依从性降低、代谢控制不良、更高的并发症发生率、生活质量下降、医疗保健使用率和成本增加、残疾和生产力丧失增加以及死亡风险增加有关。
糖尿病和抑郁症共存与严重的发病率、死亡率和增加的医疗保健成本有关。需要采取协调一致的临床护理策略，以改善临床结果并减轻疾病负担。
