Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, 3001 Heverlee (Leuven), Belgium.
Res Dev Disabil. 2010 May-Jun;31(3):634-41. doi: 10.1016/j.ridd.2010.01.002. Epub 2010 Feb 23.
To examine whether children with a 22q11.2 Deletion syndrome (22q11.2DS) are able to use prospective control, 21 children with 22q11.2DS (mean age=9.6+/-1.9; mean FSIQ=73.05+/-10.2) and 21 control children (mean age=9.6+/-1.9; mean FSIQ=73.38+/-12.0) were asked to perform a visuo-manual tracking task in which they had to track a cursor rhythmically between 2 target zones. Children with 22q11.2DS performed worse than the age- and IQ-matched controls (higher absolute time and distance errors) suggesting that the 22q11.2DS group experiences an additional (syndrome specific) processing deficit that cannot be attributed to their lower intellectual abilities. The 22q11.2DS group neither the control group improved their tracking performance throughout five identical full feedback conditions of the tracking task possibly due to a slow visuo-motor adaptation process, a short span of attention and cognitive flexibility impairments. The results showed that both the 22q11.2DS group and the controls had difficulties anticipating the movement of the target (prospective control) and thus are assumed to rely more on feedback instead of on an internal representation of the movement.
为了检验 22q11.2 缺失综合征（22q11.2DS）患儿是否能够使用前瞻性控制，我们对 21 名 22q11.2DS 患儿（平均年龄=9.6+/-1.9；平均 FSIQ=73.05+/-10.2）和 21 名对照儿童（平均年龄=9.6+/-1.9；平均 FSIQ=73.38+/-12.0）进行了视动追踪任务测试，要求他们在两个目标区域之间有节奏地追踪光标。22q11.2DS 患儿的表现比年龄和智商匹配的对照组差（绝对时间和距离误差更高），这表明 22q11.2DS 组存在额外的（综合征特异性）处理缺陷，不能归因于他们较低的智力能力。22q11.2DS 组和对照组都没有在追踪任务的五个相同全反馈条件下改善他们的追踪表现，这可能是由于视觉运动适应过程缓慢、注意力持续时间短和认知灵活性受损。结果表明，22q11.2DS 组和对照组都难以预测目标的运动（前瞻性控制），因此，他们可能更多地依赖于反馈，而不是对运动的内部表示。
