Department of Biochemistry, Institute for Medical Research Israel-Canada, Hebrew University Hadassah Medical School, POB 12272, Jerusalem 91120, Israel.
Trends Immunol. 2010 May;31(5):199-204. doi: 10.1016/j.it.2010.01.005. Epub 2010 Feb 22.
Protein inhibitor of activated STAT3 (PIAS3), the main cellular inhibitor of signal transducers and activator of transcription 3 (STAT3), has been described as a modulator of DNA binding transcription factors. The exploration of the emerging roles of PIAS3 in immune regulation is a growing and fascinating field. Recent discoveries have shed new light on the key role of PIAS3 in the regulation of transcriptional activity, and on the molecular mechanism involved. These findings suggest that the known functions of this signalling molecule are merely the "tip of the iceberg". This article reviews the challenging questions regarding the link between PIAS3 and the intracellular signalling in immune cells. Some of the known functions of PIAS3 that potentially modulate key proteins in the immune system will also be discussed.
激活 STAT3 的蛋白抑制剂（PIAS3）是信号转导和转录激活因子 3（STAT3）的主要细胞抑制剂，已被描述为 DNA 结合转录因子的调节剂。探索 PIAS3 在免疫调节中的新兴作用是一个不断发展和引人入胜的领域。最近的发现揭示了 PIAS3 在调节转录活性及其涉及的分子机制中的关键作用。这些发现表明，这种信号分子的已知功能仅仅是“冰山一角”。本文综述了关于 PIAS3 与免疫细胞内信号之间联系的具有挑战性的问题。还将讨论 PIAS3 的一些已知功能，这些功能可能调节免疫系统中的关键蛋白。
