腹内侧神经节隆起的祖细胞区需要 Nkx2-1 来产生大部分苍白球，但很少产生新皮层中间神经元。
The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.
机构信息
Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158-2611, USA.
出版信息
J Neurosci. 2010 Feb 24;30(8):2812-23. doi: 10.1523/JNEUROSCI.4228-09.2010.
Abstract
We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage produces parvalbumin(+) GABAergic neurons, ChAT(+) cholinergic neurons, and oligodendrocytes. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. Finally, our analysis provided evidence for a novel cellular component (Nkx2-1(-);Npas1(+)) of the globus pallidus.
摘要
我们通过使用 Shh-Cre 等位基因进行基因标记，证明了大多数苍白球神经元，但非常少的新皮层中间神经元，是由腹内侧神经节隆起和背侧视前区产生的。Shh 表达的基板谱系产生了 parvalbumin(+)GABA 能神经元、ChAT(+)胆碱能神经元和少突胶质细胞。Shh 表达区 Nkx2-1 功能的缺失消除了大多数苍白球神经元，而大多数皮质和纹状体中间神经元继续产生，除了纹状体胆碱能神经元。最后，我们的分析为苍白球的一个新的细胞成分（Nkx2-1(-);Npas1(+))提供了证据。
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