苍白球神经元的起源和分子特征。
Origin and molecular specification of globus pallidus neurons.
机构信息
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Sant Joan d'Alacant, Spain.
出版信息
J Neurosci. 2010 Feb 24;30(8):2824-34. doi: 10.1523/JNEUROSCI.4023-09.2010.
Abstract
The mechanisms controlling the assembly of brain nuclei are poorly understood. In the forebrain, it is typically assumed that the formation of nuclei follows a similar sequence of events that in the cortex. In this structure, projection neurons are generated sequentially from common progenitor cells and migrate radially to reach their final destination, whereas interneurons are generated remotely and arrive to the cortex through tangential migration. Using the globus pallidus as a model to study the formation of forebrain nuclei, we found that the development of this basal ganglia structure involves the generation of several distinct classes of projection neurons from relatively distant progenitor pools, which then assemble together through tangential migration. Our results thus suggest that tangential migration in the forebrain is not limited to interneurons, as previously thought, but also involves projection neurons and reveal that the assembly of forebrain nuclei is more complex than previously anticipated.
摘要
大脑核团的组装机制尚不清楚。在前脑，人们通常假设核团的形成遵循与皮层类似的事件序列。在这个结构中，投射神经元由共同的祖细胞顺序产生，并径向迁移到达最终目的地，而中间神经元则从远处产生，并通过切线迁移到达皮层。使用苍白球作为研究前脑核团形成的模型，我们发现，这个基底节结构的发育涉及到从相对较远的祖细胞池中产生几种不同类型的投射神经元，然后通过切线迁移聚集在一起。因此，我们的结果表明，以前认为前脑的切线迁移不仅限于中间神经元，还涉及投射神经元，并揭示了前脑核团的组装比以前预期的更为复杂。
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