SSEHS, Loughborough University, Leicestershire, UK.
J Alzheimers Dis. 2010;21(1):15-34. doi: 10.3233/JAD-2010-080785.
Visual impairment is a common symptom of Alzheimer's disease (AD). Recent studies have demonstrated the potential of visual interventions to improve the functioning of AD patients. Therefore, clarification of the profile of visual deficits in AD and possible mechanisms underlying these deficits are needed. This review focuses on three areas as mechanisms for the visual impairment in AD: 1) the broad-band pathway deficit; 2) glaucoma; and 3) the relative dysfunction of the ventral and dorsal streams of vision. While much research has been produced with regard to these areas, methodological flaws and lack of continuity between studies has led to conflicting findings. Nevertheless, recent imaging research suggests that the loss of retinal ganglion cells in AD may play an important role in the visual deficit in AD. This review looks to critically evaluate current research and highlight the need to investigate recent significant findings in primary vision research in understanding the impairment of vision in AD.
视力障碍是阿尔茨海默病（AD）的常见症状。最近的研究表明，视觉干预有可能改善 AD 患者的功能。因此，需要阐明 AD 患者的视觉缺陷特征以及这些缺陷的潜在机制。本综述重点关注 AD 中视觉障碍的三个机制领域：1）宽带通路缺陷；2）青光眼；以及 3）腹侧和背侧视觉流的相对功能障碍。尽管在这些领域已经进行了大量的研究，但方法上的缺陷以及研究之间缺乏连续性导致了相互矛盾的发现。然而，最近的影像学研究表明，AD 中视网膜神经节细胞的丧失可能在 AD 中的视觉缺陷中起重要作用。本综述旨在批判性地评估当前的研究，并强调需要研究初级视觉研究中的最新重要发现，以了解 AD 中视力障碍的原因。
