高氧对支气管对吸入乙酰甲胆碱反应的影响。

Effect of hyperoxia on bronchial response to inhaled methacholine.

作者信息

Wollner A, Ben-Dov I, Bar-Yishay E

机构信息

Internal Medicine Department, Hadassah, University Hospital, Mt. Scopus Jerusalem, Israel.

出版信息

Allergy. 1991 Jan;46(1):35-9. doi: 10.1111/j.1398-9995.1991.tb00540.x.

DOI:10.1111/j.1398-9995.1991.tb00540.x

PMID:2018207

Abstract

Bronchial reactivity to methacholine (MCH) under normoxic and hyperoxic conditions was studied in a double-blind controlled study in 10 normal subjects and nine asthmatic patients. The normal volunteers were challenged while breathing dry, 21% and 100% O2, and the maximal percent falls in forced expired volume in is (FEV1) following inhalation of the highest concentration of MCH (64 mg/ml) were 8 +/- 5% and 9 +/- 8%, respectively; P = NS. The asthmatic patients had their MCH challenge breathing the same gas composition and the provocative concentrations that caused a 20% fall in FEV1 (PC20) were 0.18 mg/ml (range 0.06-5.73) and 0.25 mg/ml (range 0.07-8.49), respectively, which were statistically not significantly different. We conclude that in humans, 100% O2 does not affect bronchial reactivity to MCH.

摘要

在一项双盲对照研究中，对10名正常受试者和9名哮喘患者在常氧和高氧条件下对乙酰甲胆碱（MCH）的支气管反应性进行了研究。正常志愿者在呼吸干燥的21%氧气和100%氧气时接受激发试验，吸入最高浓度MCH（64mg/ml）后第一秒用力呼气量（FEV1）的最大下降百分比分别为8±5%和9±8%；P=无显著性差异。哮喘患者在呼吸相同气体成分时接受MCH激发试验，导致FEV1下降20%的激发浓度（PC20）分别为0.18mg/ml（范围0.06 - 5.73）和0.25mg/ml（范围0.07 - 8.49），在统计学上无显著差异。我们得出结论，在人类中，100%氧气不影响支气管对MCH的反应性。