Department of Ophthalmology, University of California San Francisco, USA.
J Neuroophthalmol. 2010 Mar;30(1):64-6. doi: 10.1097/WNO.0b013e3181c25698.
Lupus erythematosus profundus (LEP) is an uncommon subtype of lupus erythematosus. A 76-year old man presented with inflammation of the eyelids and underlying orbital soft tissue. A biopsy disclosed inflammation and atrophy of the orbital fat consistent with LEP. Systemic corticosteroid treatment produced resolution of the inflammation. but as the edema subsided, enophthalmos became apparent. LEP should be considered in patients with a characteristic rash and orbital inflammation and may cause acquired enophthalmos.
深部红斑狼疮（LEP）是红斑狼疮的一种罕见亚型。一位 76 岁男性因眼睑和眼眶内软组织炎症就诊。活检显示眼眶脂肪存在炎症和萎缩，符合深部红斑狼疮的特征。全身皮质类固醇治疗使炎症得到缓解，但随着水肿消退，出现眼球内陷。对于具有特征性皮疹和眼眶炎症的患者，应考虑深部红斑狼疮，其可能导致获得性眼球内陷。
