Department of Orthopaedic Surgery, University of Missouri, Columbia, MO, USA.
J Orthop Trauma. 2010 Mar;24 Suppl 1:S31-5. doi: 10.1097/BOT.0b013e3181cde5d1.
Parathyroid hormone is a well-known regulator of calcium metabolism in the body. It binds to osteoblasts and assists in the regulation of bone turnover. Changes in parathyroid hormone levels have been documented in pathologic states such as osteoporosis, and fluxes are also noted during healing of fractures. Because fracture healing requires time and is sometimes unreliable, a search for fracture-healing adjuvants that accelerate the healing rate and improve reliability of healing is compelling. Parathyroid hormone, as a systemic mediator of calcium and bone metabolism, is a good candidate. Much research has been accomplished in animal models examining the role of parathyroid hormone in fracture healing. Although further research is required, especially in human fracture patients, early indicators are that parathyroid hormone may play a role in accelerating fracture healing in healthy patients and in reducing rates of fracture nonunion in compromised patients or tissue beds.
甲状旁腺激素是体内钙代谢的重要调节剂。它与成骨细胞结合，有助于调节骨转换。在骨质疏松等病理状态下已经记录到甲状旁腺激素水平的变化，在骨折愈合过程中也会出现变化。由于骨折愈合需要时间，并且有时不可靠，因此寻找可加速愈合率并提高愈合可靠性的骨折愈合佐剂是非常有必要的。甲状旁腺激素作为钙和骨代谢的全身调节剂，是一个很好的候选药物。已经在动物模型中进行了大量研究，以研究甲状旁腺激素在骨折愈合中的作用。尽管还需要进一步的研究，特别是在人类骨折患者中，早期的迹象表明甲状旁腺激素可能在加速健康患者的骨折愈合以及降低受损患者或组织床骨折不愈合的发生率方面发挥作用。
