Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA, USA.
J Orthop Trauma. 2010 Mar;24 Suppl 1:S4-8. doi: 10.1097/BOT.0b013e3181ca3fab.
Fracture healing is a biologically optimized process. Despite the expectation of unimpaired healing, approximately 5% to 10% of the 7.9 million fractures sustained annually in the United States have difficulty achieving union. Not only does this cause morbidity for patients, but also enormous healthcare and socioeconomic costs. Hence, there is a compelling need to find novel therapies to enhance fracture healing. In this article, we summarize current data on therapies to enhance skeletal healing and review their suggested biologic functions, proposed clinical applications, and known efficacies.
骨折愈合是一个生物优化的过程。尽管人们期望能够不受影响地愈合，但在美国每年发生的 790 万例骨折中，仍有约 5%至 10%的骨折难以愈合。这不仅给患者带来了发病率，还造成了巨大的医疗保健和社会经济成本。因此，迫切需要寻找新的治疗方法来增强骨折愈合。本文总结了目前关于增强骨骼愈合的治疗方法的数据，并回顾了它们的建议的生物学功能、提出的临床应用和已知的疗效。
