Division of Orthopaedics, Department of Surgery, University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada.
J Orthop Trauma. 2010 Mar;24 Suppl 1:S17-24. doi: 10.1097/BOT.0b013e3181cec6fb.
Traumatic bone defects and nonunion represent a significant source of morbidity and socioeconomic burden in trauma patients. The treatment of these conditions is currently hampered by inadequate therapies. This has prompted a new era of investigation into biologic therapies for augmenting fracture healing. Within this body of research, gene therapy has arisen as a novel and effective method of delivering therapeutic proteins at a site of desired bone regeneration. Gene therapy has shown tremendous potential in preclinical studies of fracture healing, but to date, no clinical trials have occurred. This article reviews the scientific basis for gene therapy in fracture healing, provides an overview of important preclinical studies that have been performed to date, and discusses the current barriers and future directions of gene therapy as it applies to fracture healing.
创伤性骨缺损和骨不连是创伤患者发病率和社会经济负担的重要来源。目前，这些疾病的治疗受到治疗方法不足的限制。这促使人们对生物治疗方法进行了新的研究，以增强骨折愈合。在这一研究领域中，基因治疗作为一种在所需骨再生部位递送治疗性蛋白的新的有效方法已经出现。基因治疗在骨折愈合的临床前研究中显示出了巨大的潜力，但迄今为止，尚未进行临床试验。本文综述了基因治疗在骨折愈合中的科学基础，概述了迄今为止已进行的重要临床前研究，并讨论了基因治疗在骨折愈合中的当前障碍和未来方向。
