Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany.
J Orthop Trauma. 2010 Mar;24(3):181-7. doi: 10.1097/BOT.0b013e3181bae887.
The objective of this study was to compare bone mineral density and content measurements by dual-energy x-ray absorptiometry with bone stiffness measurements as indicators of the load-bearing capacity of regenerating bone during distraction osteogenesis.
The study analyzed ex vivo a set of 26 sheep bone specimens after distraction osteogenesis. Bone mineral density and bone mineral content were measured by dual-energy x-ray absorptiometry. Biomechanical parameters such as torsional, compressive, and bending stiffness were determined using a material testing system. The maximum torsional moment applied at fracture is used to determine the load-bearing capacity of the bone.
The correlation between stiffness measurements and the load-bearing capacity of a bone is significantly greater than the correlation between load-bearing capacity and bone mineral density and content measurements by dual-energy x-ray absorptiometry.
The results of this ex vivo study indicate that stiffness measurements are a better quantitative indicator of the load-bearing capacity of a bone and thus of bone healing than bone mineral density and content measurements by dual-energy x-ray absorptiometry. The results of the current study do not confirm previous work that showed that there is a significant correlation between bone material quality obtained by dual-energy x-ray absorptiometry and bone strength.
本研究旨在比较双能 X 射线吸收法测量的骨矿物质密度和含量与骨刚度测量值，以评估在牵张成骨过程中再生骨的承重能力。
本研究对 26 个羊骨标本进行了离体分析，这些标本均经过牵张成骨处理。采用双能 X 射线吸收法测量骨矿物质密度和骨矿物质含量。使用材料测试系统确定扭转、压缩和弯曲刚度等生物力学参数。骨折时施加的最大扭转力矩用于确定骨的承重能力。
与骨矿物质密度和含量的双能 X 射线吸收法测量值相比，刚度测量值与骨承重能力之间的相关性显著更高。
这项离体研究的结果表明，与双能 X 射线吸收法测量的骨矿物质密度和含量相比，刚度测量值是评估骨承重能力和骨愈合的更好的定量指标。本研究的结果并未证实先前的研究结果，即双能 X 射线吸收法获得的骨材料质量与骨强度之间存在显著相关性。
