Bowles M H, Klonis D, Plavac T G, Gonzales B, Francisco D A, Roberts R W, Boxberger G R, Poliner L R, Galichia J P
Wichita Institute for Clinical Research, Kansas.
Angiology. 1991 Mar;42(3):187-94. doi: 10.1177/000331979104200302.
The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal coronary angioplasty (PTCA). After six months of therapy, participants were subjected to coronary arteriography, exercise scintigraphy, exercise electrocardiography, or clinical evaluation. Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33% of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis greater than or equal to 35% were associated with restenosis. Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates.
在接受冠状动脉球囊血管成形术的患者中评估了鱼油对再狭窄的影响。除常规药物治疗外，研究对象每天服用2.8克二十碳五烯酸（EPA）。治疗在成功的经皮腔内冠状动脉成形术（PTCA）后二十四小时内开始。经过六个月的治疗后，参与者接受冠状动脉造影、运动闪烁扫描、运动心电图或临床评估。随访评估涉及85例患者的97处冠状动脉病变。36.5%的患者和33%的血管出现了部分或显著再狭窄。PTCA前严重狭窄、夹层、血栓、多病变PTCA的存在以及模板出血时间值与再狭窄无关。左前降支（LAD）扩张以及残余狭窄大于或等于35%与再狭窄相关。约20%的患者表示服用鱼油有困难。此外，这些结果显示与预期的再狭窄率相比并无优势。
