Isabella G, Ramondo A, Cardaioli P, Reimers B, Pasquetto G, Carasi M, Razzolini R, Chioin R
Servizio di Emodinamica e Cardiologia Interventistica, Università degli Studi, Padova.
G Ital Cardiol. 1995 Sep;25(9):1127-38.
Percutaneous transluminal coronary angioplasty (PTCA) in complex coronary lesions (type B2 and C of the modified AHA/ACC classification) presents a lower primary success rate and higher risk of dissection than type A and B1 lesions. An alternative approach to this lesions is coronary rotational ablation (Rotablator, Heart Technology) with complementary PTCA using low inflation pressures ("facilitated angioplasty").
Twenty-six type B2 and C lesions in 24 patients (pts) (8 female, 16 male, age 37-80 years) were treated with coronary rotational ablation and complementary PTCA between January 1993 and December 1994 (4.7% of all interventional coronary procedures performed in this period in our laboratory). Eleven pts had stable effort angina and 13 pts had unstable, class IB, IIB, and IIC, angina. The treated vessel was the LAD in 15 cases, CX in 5, RCA in 5, and an intermediate branch in one case. Coronary rotational ablation was proposed because of the presence of two or more risk factors for uneffective or complicated PTCA: eccentricity, calcified lesions, bifurcation stenosis, lesion length > 10 mm, severe stenosis (90-99%), ostial location and bend location (45-60 degrees). No lesion showed coronary thrombus, considered as absolute contraindication to coronary rotational ablation. We used small burrs (burr/artery ratio < 0.75), and complementary PTCA was performed using low inflation pressure (< 8 atm) and long balloons for long lesions (> 10 mm) in order to minimize the risk of dissection.
Coronary rotational ablation was successfully performed in all but two cases (24/26; 92.3%), with a reduction of the stenosis from 88 +/- 9% to 45 +/- 10% (range 30-60%). In two pts (7.7%) the procedure was complicated by acute occlusion: both pts underwent effective salvage PTCA with 30% residual stenosis. Small type A and B dissections occurred in 4/26 cases (15.4%). All but one lesions complicated by acute occlusion or dissection following coronary rotational ablation were not or only slightly calcified. Complementary PTCA was performed in all but two pts who already presented 30% residual stenosis after rotational ablation. A further reduction of stenosis to 20 +/- 9% (range 5-30%) was achieved. After complementary PTCA four pts (15.4%) developed type A and B dissections; in one of these a Palmaz-Schatz stent was implanted, whereas the remaining three pts presented a residual stenosis below 30% and no further procedures were undertaken. Overall success rate of rotational atherectomy plus salvage or complementary PTCA or stenting was 100%, and no major complications (Q-wave myocardial infarction, emergency bypass surgery or death) occurred. Three pts showed delayed coronary run-off (slow reflow) after rotational ablation, and two of these released a small amount of cardiac specific enzymes (CK MB) without ECG changes and wall motion alteration on echocardiographic examination. Clinical restenosis, defined as recurrent angina and/or positive exercise stress test, developed in 45.8% (11 pts); in all these pts restenosis was angiographically evidenced (75-99%).
Our experience suggests that coronary rotational ablation along with complementary PTCA using low inflation pressure and long balloons is safe and effective in type B2 and C lesions if calcifications are present; however, restenosis rate remains high.
在复杂冠状动脉病变(改良的美国心脏协会/美国心脏病学会分类中的B2型和C型)中,经皮腔内冠状动脉成形术(PTCA)的初始成功率低于A型和B1型病变,且夹层形成风险更高。对于此类病变,一种替代方法是采用冠状动脉旋磨术(Rotablator,Heart Technology公司),并辅助使用低压力球囊扩张的PTCA(“简易血管成形术”)。
1993年1月至1994年12月期间,对24例患者(8例女性,16例男性,年龄37 - 80岁)的26处B2型和C型病变进行了冠状动脉旋磨术及辅助PTCA治疗(占同期本实验室所有冠状动脉介入手术的4.7%)。11例患者有稳定型劳力性心绞痛,13例患者有不稳定型心绞痛(IB级、IIB级和IIC级)。治疗的血管中,左前降支15例,回旋支5例,右冠状动脉5例,中间支1例。因存在两个或更多导致PTCA无效或复杂的危险因素而采用冠状动脉旋磨术:偏心性、钙化病变、分叉处狭窄、病变长度>10 mm、严重狭窄(90 - 99%)、开口处病变及弯曲处病变(45 - 60度)。所有病变均未显示冠状动脉血栓,冠状动脉血栓被视为冠状动脉旋磨术的绝对禁忌证。我们使用小号磨头(磨头/动脉直径比<0.75),辅助PTCA采用低压力球囊扩张(<8个大气压),对于长病变(>10 mm)使用长球囊,以尽量降低夹层形成风险。
除2例(24/26;92.3%)外,所有病例均成功完成冠状动脉旋磨术,狭窄程度从88±9%降至45±10%(范围30 - 60%)。2例患者(7.7%)手术出现急性闭塞并发症:这2例患者均接受了有效的挽救性PTCA,残余狭窄30%。26例中有4例(15.4%)出现小型A型和B型夹层。冠状动脉旋磨术后出现急性闭塞或夹层的所有病变中,除1例病变外均无钙化或仅有轻微钙化。除2例旋磨术后残余狭窄已达30%的患者外,所有患者均接受了辅助PTCA。狭窄程度进一步降至20±9%(范围5 - 30%)。辅助PTCA后,4例患者(15.4%)出现A型和B型夹层;其中1例植入了Palmaz - Schatz支架,其余3例残余狭窄低于30%,未再进行进一步治疗。旋磨术联合挽救性或辅助性PTCA或支架置入的总体成功率为100%,未发生严重并发症(Q波心肌梗死、急诊搭桥手术或死亡)。3例患者旋磨术后出现延迟性冠状动脉血流缓慢(慢血流),其中2例释放了少量心肌特异性酶(CK MB),心电图无变化,超声心动图检查未发现室壁运动改变。临床再狭窄定义为复发性心绞痛和/或运动负荷试验阳性,发生率为45.8%(11例患者);所有这些患者经血管造影证实存在再狭窄(75 - 99%)。
我们的经验表明,对于存在钙化的B2型和C型病变,冠状动脉旋磨术联合使用低压力球囊扩张及长球囊辅助PTCA是安全有效的;然而,再狭窄率仍然较高。