Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Pancreas. 2010 Aug;39(6):829-35. doi: 10.1097/MPA.0b013e3181ca3da4.
There have been few epidemiological studies on pancreatic diabetes. In this study, we determined the incidence and pathology of pancreatic diabetes in Japan.
We examined the epidemiology of pancreatic diabetes in Japan in 2005 by using a nationwide stratified random-sampling method. Especially, we focused on newly developed diabetes in association with the occurrence of pancreatic disease (true pancreatic diabetes).
A total of 19,500 individuals received treatment for true pancreatic diabetes, accounting for 0.8% of patients with diabetes. Prevalence was estimated to be 15.2 per 100,000 with an annual onset incidence of 1.1 per 100,000. With regard to the complications in true pancreatic diabetes, the incidence of retinopathy was lower than that in types 1 and 2 diabetes. Among true pancreatic diabetes with chronic pancreatitis, alcoholic pancreatitis was found in the largest sector. Furthermore, as many as 53.7% were continuous drinkers, and 66.7% received insulin therapy. The frequency of hypoglycemia was high in regular drinkers treated with insulin. Hypoglycemia was a major cause of death in patients who were on insulin and continuous drinkers.
We clarified the epidemiology of pancreatic diabetes in Japan. Patients with chronic pancreatitis-associated pancreatic diabetes should receive lifestyle guidance focused on drinking cessation.
有关胰腺性糖尿病的流行病学研究较少。本研究旨在确定日本胰腺性糖尿病的发病情况和病理学特征。
我们采用全国分层随机抽样方法，于 2005 年对日本胰腺性糖尿病的流行病学进行了研究。特别关注与胰腺疾病相关的新发糖尿病（真正的胰腺性糖尿病）。
共有 19500 例患者接受真正的胰腺性糖尿病治疗，占糖尿病患者的 0.8%。估计患病率为每 10 万人 15.2 例，年发病 1.1 例/10 万人。在真正的胰腺性糖尿病的并发症方面，视网膜病变的发生率低于 1 型和 2 型糖尿病。在慢性胰腺炎相关的真正胰腺性糖尿病中，酒精性胰腺炎占比最大。此外，多达 53.7%的患者为持续饮酒者，66.7%接受胰岛素治疗。持续饮酒且接受胰岛素治疗的患者低血糖发生频率较高。低血糖是接受胰岛素治疗且持续饮酒者死亡的主要原因。
我们阐明了日本胰腺性糖尿病的流行病学特征。患有慢性胰腺炎相关胰腺性糖尿病的患者应接受以戒酒为重点的生活方式指导。
