Qi Linlong, Liang Xiaoyao, Qin Zirui, Gao Huihui, Zhang Yi, Wang Yuan, Deng Shuli
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China.
Stem Cells Int. 2025 Aug 31;2025:5523197. doi: 10.1155/sci/5523197. eCollection 2025.
Dental mesenchymal stem cells (MSCs) play an essential role in the development of immature permanent teeth. Bacterial infection of the pulp and periapical tissues of immature permanent teeth, the associated oral pathogens, and their virulence factors affect the viability, proliferation, differentiation, and cytokine secretion of MSCs. Bacteria and virulence factors can also trigger an inflammatory response that induces pro-inflammatory cytokine secretion and destroys odontogenic MSCs in the pulp and periapical region, negatively affecting the development of immature permanent teeth. The present study explored the role and mechanisms of oral pathogens associated with pulpitis and apical periodontitis and their virulence factors concerning odontogenic MSCs. The findings can contribute to the clinical treatment of pulpitis and apical periodontitis of immature permanent teeth, providing a theoretical basis for improving its clinical efficacy.
牙间充质干细胞（MSCs）在未成熟恒牙的发育中起着至关重要的作用。未成熟恒牙牙髓和根尖周组织的细菌感染、相关口腔病原体及其毒力因子会影响MSCs的活力、增殖、分化和细胞因子分泌。细菌和毒力因子还可引发炎症反应，诱导促炎细胞因子分泌，并破坏牙髓和根尖周区域的成牙本质MSCs，对未成熟恒牙的发育产生负面影响。本研究探讨了与牙髓炎和根尖周炎相关的口腔病原体及其毒力因子对成牙本质MSCs的作用和机制。这些发现有助于未成熟恒牙牙髓炎和根尖周炎的临床治疗，为提高其临床疗效提供理论依据。
