Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1.
J Oncol. 2010;2010:514310. doi: 10.1155/2010/514310. Epub 2010 Feb 17.
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer and also one of the most poorly understood. Other health issues that are affecting women with increasing frequency are obesity and diabetes, which are associated with dysglycemia and increased blood glucose. The Warburg Effect describes the ability of fast-growing cancer cells to preferentially metabolize glucose via anaerobic glycolysis rather than oxidative phosphorylation. Recent epidemiological studies have suggested a role for hyperglycemia in the pathogenesis of a number of cancers. If hyperglycemia contributes to tumour growth and progression, then it is intuitive that antihyperglycemic drugs may also have an important antitumour role. Preliminary reports suggest that these drugs not only reduce available plasma glucose, but also have direct effects on cancer cell viability through modification of molecular energy-sensing pathways. This review investigates the effect that hyperglycemia may have on EOC and the potential of antihyperglycemic drugs as therapeutic adjuncts.
上皮性卵巢癌（EOC）是最致命的妇科癌症，也是最不被了解的癌症之一。其他越来越频繁影响女性的健康问题是肥胖症和糖尿病，这些问题与血糖异常和血糖升高有关。沃伯格效应描述了快速生长的癌细胞通过无氧糖酵解而不是氧化磷酸化优先代谢葡萄糖的能力。最近的流行病学研究表明，高血糖在多种癌症的发病机制中起作用。如果高血糖有助于肿瘤的生长和进展，那么直观地说，抗高血糖药物也可能具有重要的抗肿瘤作用。初步报告表明，这些药物不仅降低了可用的血浆葡萄糖，而且通过改变分子能量感应途径对癌细胞活力产生直接影响。本综述探讨了高血糖对 EOC 的影响以及抗高血糖药物作为治疗辅助剂的潜力。
