Sharafutdinova K I, Shlyapina V S, Baeva A I, Timurshin A A, Sabanaeva I E, Nakieva A G, Kalashnikova M F, Khabibov M N
First Moscow State Medical University (Sechenov University).
Russian National Research Medical University named after N.I. Pirogov.
Probl Endokrinol (Mosk). 2023 Jun 30;69(3):103-110. doi: 10.14341/probl13282.
The article discusses various pathophysiological conditions and processes that lead to the development of tumors in diabetes mellitus. These include obesity, hyperglycemia, hyperinsulinemia, inflammation, and oxidative stress. The data of epidemiological studies are given, in which it was found that diabetes mellitus (both type 1 and type 2) increases the risk of developing the female reproductive system tumors, such as ovarian cancer, endometrial cancer, while for cervical cancer, vaginal cancer and vulvar cancer, such a relationship has not been clearly identified.
本文讨论了导致糖尿病患者发生肿瘤的各种病理生理状况和过程。这些包括肥胖、高血糖、高胰岛素血症、炎症和氧化应激。文中给出了流行病学研究数据,其中发现糖尿病(1型和2型)会增加女性生殖系统肿瘤的发病风险,如卵巢癌、子宫内膜癌,而对于宫颈癌、阴道癌和外阴癌,尚未明确这种关系。