Kc Ravi, Henry Ian D, Park Gregory H J, Aghdasi Al, Raftery Daniel
Department of Chemistry, Purdue University, West Lafayette, IN 47907.
Concepts Magn Reson Part B Magn Reson Eng. 2010 Feb 17;37B(1):13-19. doi: 10.1002/cmr.b.20152.
We present the construction and performance of a 20-μL active volume probe that utilizes zero-susceptibility wire for the detection transceiver coil and a 3.5 mm outer diameter thin-wall bubble flow cell to contain the sample. The probe shows good rf homogeneity, resolution, line shape and sensitivity. The sensitivity and resolution of the 20-μL probe was compared to those for several other coil configurations, including smaller detection volumes, a thin wire copper coil immersed in susceptibility matching perfluorocarbon FC-43 (fluorinert) fluid, and a standard 5 mm probe. In particular, the (1)H mass sensitivity, S(m) (SNR per micromole), was 3-4 fold higher than that for the standard 5 mm probe. Finally, the use of the zero-susceptibility wire in smaller volume probes is discussed along with potential future improvements and applications.
我们展示了一种20微升有效体积探头的构建与性能，该探头在检测收发线圈中采用了零磁化率导线，并使用外径为3.5毫米的薄壁气泡流通池来容纳样品。该探头具有良好的射频均匀性、分辨率、线形和灵敏度。将20微升探头的灵敏度和分辨率与其他几种线圈配置的进行了比较，包括较小的检测体积、浸没在磁化率匹配的全氟碳FC - 43（氟化物）流体中的细铜丝线圈以及标准的5毫米探头。特别是，质子质量灵敏度S(m)（每微摩尔的信噪比）比标准5毫米探头高3至4倍。最后，讨论了在较小体积探头中使用零磁化率导线的情况以及未来潜在的改进和应用。
