微线圈核磁共振波谱法。

Microcoil nuclear magnetic resonance spectroscopy.

作者信息

Webb A G

机构信息

Department of Electrical and Computer Engineering, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 4221 Beckman Institute, 405 N. Mathews, Urbana, IL 61801, USA.

出版信息

J Pharm Biomed Anal. 2005 Aug 10;38(5):892-903. doi: 10.1016/j.jpba.2005.01.048.

DOI:10.1016/j.jpba.2005.01.048

PMID:16087050

Abstract

In comparison with most analytical chemistry techniques, nuclear magnetic resonance has an intrinsically low sensitivity, and many potential applications are therefore precluded by the limited available quantity of certain types of sample. In recent years, there has been a trend, both commercial and academic, towards miniaturization of the receiver coil in order to increase the mass sensitivity of NMR measurements. These small coils have also proved very useful in coupling NMR detection with commonly used microseparation techniques. A further development enabled by small detectors is parallel data acquisition from many samples simultaneously, made possible by incorporating multiple receiver coils into a single NMR probehead. This review article summarizes recent developments and applications of "microcoil" NMR spectroscopy.

摘要

与大多数分析化学技术相比，核磁共振的灵敏度天生较低，因此许多潜在应用因某些类型样品的可用量有限而无法实现。近年来，无论是商业领域还是学术领域，都有将接收线圈小型化的趋势，以提高核磁共振测量的质量灵敏度。这些小线圈在将核磁共振检测与常用的微分离技术相结合方面也证明非常有用。小型探测器带来的进一步发展是能够同时从多个样品中并行采集数据，这通过将多个接收线圈集成到单个核磁共振探头中得以实现。这篇综述文章总结了“微线圈”核磁共振光谱的最新发展和应用。