未来有望用于治疗多发性硬化症的疗法。
Promising treatments of tomorrow for multiple sclerosis.
作者信息
Harrison Daniel M, Calabresi Peter A
机构信息
Johns Hopkins Multiple Sclerosis Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Ann Indian Acad Neurol. 2009 Oct;12(4):283-90. doi: 10.4103/0972-2327.58279.
The therapeutic options for multiple sclerosis are rapidly expanding. What was once seen as a disease with little hope for treatment is now a target of rapid drug development. Current therapies have demonstrated efficacy in limiting the impact of the disease, but none is fully effective in all patients. However, promising new treatments are on the horizon. In this review we will discuss potential novel immunomodulating drugs that are in advanced stages of investigation; these drugs include monoclonal antibodies, chimeric molecules, and oral therapies. The use of hematopoietic stem cells will also be discussed and, in addition, we will look farther ahead at possible novel targets for the development of new immunomodulatory or neuroprotective pharmaceuticals.
多发性硬化症的治疗选择正在迅速增加。曾经被视为几乎没有治疗希望的疾病，如今已成为药物快速研发的目标。目前的疗法已证明在限制疾病影响方面具有疗效，但没有一种疗法对所有患者都完全有效。然而，有前景的新疗法即将出现。在本综述中，我们将讨论处于研究后期的潜在新型免疫调节药物；这些药物包括单克隆抗体、嵌合分子和口服疗法。还将讨论造血干细胞的使用，此外，我们将更前瞻性地探讨新型免疫调节或神经保护药物开发的可能新靶点。
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