用于治疗神经退行性疾病的干细胞。
Stem cells for the treatment of neurodegenerative diseases.
机构信息
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL 32827, USA.
出版信息
Stem Cell Res Ther. 2010 Dec 10;1(5):37. doi: 10.1186/scrt37.
Abstract
Stem cells offer an enormous pool of resources for the understanding of the human body. One proposed use of stem cells has been as an autologous therapy. The use of stem cells for neurodegenerative diseases has become of interest. Clinical applications of stem cells for Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis will increase in the coming years, and although great care will need to be taken when moving forward with prospective treatments, the application of stem cells is highly promising.
摘要
干细胞为了解人体提供了巨大的资源库。干细胞的一种应用形式是作为自体疗法。利用干细胞治疗神经退行性疾病已引起关注。在未来几年，干细胞在治疗阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和多发性硬化症方面的临床应用将会增加，尽管在推进前瞻性治疗时需要非常谨慎，但干细胞的应用前景非常广阔。
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2
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3
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4
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