Arrest缺陷蛋白1（ARD1）：肿瘤抑制因子还是癌蛋白？
Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein?
作者信息
Kuo Hsu-Ping, Hung Mien-Chie
出版信息
Am J Transl Res. 2010 Jan 1;2(1):56-64.
Abstract
Arrest-defect-1 protein (ARD1), an acetyltransferase, catalyzes N-alpha-acetylation in yeast. In mammalian cells, both N-alpha-acetylation and epsilon-acetylation induced by ARD1 have been reported. Emerging evidence has revealed that ARD1 is involved in a variety of cellular functions, including proliferation, apoptosis, autophagy, and differentiation and that dysregulation of ARD1 is associated with tumorigenesis and neurodegenerative disorder. This review will discuss recent discoveries regarding variations among the different ARD1 isoforms, the associated biological functions of ARD1, and ARD1 localization in different cells. We will also discuss the potential upstream regulators and downstream targets of ARD1 to provide new avenues for resolving its controversial roles in cancer development.
摘要
逮捕缺陷1蛋白（ARD1）是一种乙酰转移酶，在酵母中催化N-α-乙酰化反应。在哺乳动物细胞中，也有报道称ARD1可诱导N-α-乙酰化和ε-乙酰化。新出现的证据表明，ARD1参与多种细胞功能，包括增殖、凋亡、自噬和分化，并且ARD1的失调与肿瘤发生和神经退行性疾病有关。本综述将讨论关于不同ARD1异构体之间差异、ARD1相关生物学功能以及ARD1在不同细胞中的定位的最新发现。我们还将讨论ARD1潜在的上游调节因子和下游靶点，为解决其在癌症发展中存在争议的作用提供新途径。
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