核仁周隙。
The perinucleolar compartment.
机构信息
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
出版信息
Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a000679. doi: 10.1101/cshperspect.a000679.
Abstract
The perinucleolar compartment (PNC) is a subnuclear body characterized by its location to the periphery of the nucleolus. The PNC is a dynamic structure and is highly enriched in RNA-binding proteins and pol III RNA. The structural stability of the PNC is dependent on continuous pol III transcription and the presence of key proteins. The PNC is associated with malignancy both in vitro and in vivo and its presence positively correlates with metastatic capacity, making it a potential cancer marker. Recent studies also suggest an association between the PNC and a specific DNA locus, and ongoing PNC research continues to focus on determining the structure and function of the PNC to understand its role in cancer. This article summarizes the current understanding of PNC structure and function with an emphasis on the association of PNC and malignancy.
摘要
核仁周腔（PNC）是一种亚核结构，其特征是位于核仁的外周。PNC 是一种动态结构，富含 RNA 结合蛋白和 pol III RNA。PNC 的结构稳定性依赖于连续的 pol III 转录和关键蛋白的存在。PNC 在体外和体内都与恶性肿瘤有关，其存在与转移能力呈正相关，使其成为一种潜在的癌症标志物。最近的研究还表明 PNC 与特定的 DNA 位点之间存在关联，目前 PNC 的研究仍在继续，重点是确定 PNC 的结构和功能，以了解其在癌症中的作用。本文总结了 PNC 结构和功能的最新认识，重点介绍了 PNC 与恶性肿瘤的关联。
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