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[Assessment of serum interleukin-6 with a rapid test. The diagnosis of neonatal sepsis can be established or ruled out].[采用快速检测法评估血清白细胞介素-6。新生儿败血症的诊断可得以确立或排除]
Orv Hetil. 2007 Aug 26;148(34):1609-14. doi: 10.1556/OH.2007.27991.
2
Neonatal sepsis in very low birthweight infants at the University Hospital of the West indies.西印度群岛大学医院极低出生体重儿的新生儿败血症
West Indian Med J. 2006 Jun;55(3):165-9. doi: 10.1590/s0043-31442006000300007.
3
Can neutrophil responses in very low birth weight infants predict the organisms responsible for late-onset bacterial or fungal sepsis?极低出生体重儿的中性粒细胞反应能否预测导致晚发性细菌或真菌败血症的病原体？
J Perinatol. 2006 Aug;26(8):501-5. doi: 10.1038/sj.jp.7211554. Epub 2006 Jun 8.
4
Neonatal sepsis-- a global problem: an overview.新生儿败血症——一个全球性问题：概述
Mymensingh Med J. 2006 Jan;15(1):108-14. doi: 10.3329/mmj.v15i1.2.
5
Persistent bacteremia and severe thrombocytopenia caused by coagulase-negative Staphylococcus in a neonatal intensive care unit.新生儿重症监护病房中由凝固酶阴性葡萄球菌引起的持续性菌血症和严重血小板减少症。
Pediatrics. 2006 Feb;117(2):340-8. doi: 10.1542/peds.2005-0333.
6
Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992-2002.1992 - 2002年澳大利亚和新西兰晚发型新生儿革兰氏阴性杆菌感染情况
Pediatr Infect Dis J. 2006 Jan;25(1):25-9. doi: 10.1097/01.inf.0000195628.35980.2e.
7
Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003.极低出生体重早产且早发型新生儿败血症：2002 - 2003年美国国立儿童健康与人类发展研究所新生儿研究网络中革兰氏阴性菌感染仍占主导地位
Pediatr Infect Dis J. 2005 Jul;24(7):635-9. doi: 10.1097/01.inf.0000168749.82105.64.
8
Septicemia in the first week of life in a Norwegian national cohort of extremely premature infants.挪威全国极早产儿队列中出生后第一周的败血症。
Pediatrics. 2005 Mar;115(3):e262-8. doi: 10.1542/peds.2004-1834. Epub 2005 Feb 1.
9
Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey.极低出生体重儿晚发性败血症中病原体特异性早期死亡率：一项全国性调查。
Clin Infect Dis. 2005 Jan 15;40(2):218-24. doi: 10.1086/426444. Epub 2004 Dec 17.
10
Early enteral feeding and nosocomial sepsis in very low birthweight infants.极低出生体重儿的早期肠内喂养与医院感染性败血症
Arch Dis Child Fetal Neonatal Ed. 2004 Jul;89(4):F289-92. doi: 10.1136/adc.2002.021923.

极低出生体重巴西婴儿的脓毒症相关死亡率：铜绿假单胞菌的作用

Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role of Pseudomonas aeruginosa.

作者信息

Pereira Sylvia Maria Porto, de Almeida Cardoso Maria Helena Cabral, Figuexeds Ana Lucia, Mattos Haroldo, Rozembaum Ronaldo, Ferreira Vanessa Isidoro, Portinho Maria Antonieta, Gonçalves Ana Cristina, da Costa Elaine Sobral

机构信息

Post-Graduate Department, Fernandes Figueira Institute, Rui Barbosa Avenue, 716, Flamengo, Rio de Janeiro 22250-020, Brazil.

出版信息

Int J Pediatr. 2009;2009:427682. doi: 10.1155/2009/427682. Epub 2010 Feb 21.

DOI:10.1155/2009/427682
PMID:20182631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2825662/
Abstract

The aim of this study is to identify risk factors for sepsis-related mortality in low birth weight (<1500 g) infants. We performed retrospective cohort study to investigate risk factors for sepsis-related mortality in all neonates birth weight <1500 g admitted to Level III neonatal intensive care unit, Brazil, April 2001/September 2004. Of the 203 cases, 71 (35%) had sepsis. Of those, gram-positive was identified in 52/87 blood cultures (59.8%), the most common Coagulase-negative Staphylococcus (31/87; 35.5%). Gram-negative was present in 29 of the 87 positive blood cultures (33.3%), with Pseudomonas aeruginosa (8/87; 9.1%), the most frequent agent. Overall 21 of 71 infants with sepsis (29.6%) died. Risk factors for sepsis-related mortality were gestational age </=28 weeks, birth weight </=1000 g (9.6 times more often than birth weight >1000 g), five-minute Apgar </=7, gram-negative sepsis, mechanical ventilation (6.7 times higher than no use), and intravascular catheter. Sepsis-related mortality was due, mainly, to Pseudomonas aeruginosa; birth weight </=1000 g and mechanical ventilation were strong sepsis-related mortality predictors.

摘要

本研究旨在确定低出生体重（<1500克）婴儿败血症相关死亡的危险因素。我们进行了一项回顾性队列研究，以调查2001年4月/2004年9月在巴西三级新生儿重症监护病房收治的所有出生体重<1500克的新生儿败血症相关死亡的危险因素。在203例病例中，71例（35%）患有败血症。其中，87份血培养中有52份（59.8%）鉴定为革兰氏阳性菌，最常见的是凝固酶阴性葡萄球菌（31/87；35.5%）。87份阳性血培养中有29份（33.3%）为革兰氏阴性菌，铜绿假单胞菌（8/87；9.1%）是最常见的病原体。71例败血症婴儿中共有21例（29.6%）死亡。败血症相关死亡的危险因素包括胎龄≤28周、出生体重≤1000克（是出生体重>1000克的9.6倍）、5分钟阿氏评分≤7分、革兰氏阴性菌败血症、机械通气（比未使用机械通气高6.7倍）以及血管内导管。败血症相关死亡主要归因于铜绿假单胞菌；出生体重≤10