United States Military Cancer Institute, Walter Reed Army Medical Center, Building 1, Suite A-109, 6900 Georgia Ave, NW, Washington, DC 20307, USA.
Cancer Causes Control. 2010 Jun;21(6):853-61. doi: 10.1007/s10552-010-9512-y. Epub 2010 Feb 25.
Descriptive studies of pancreatic cancer incidence have been sparse particularly in terms of tumor histology and stage. The purpose of this study was to examine the incidence rate trends of exocrine and endocrine pancreatic cancers by demographic and tumor characteristics using data from the Surveillance, Epidemiology, and End Results (SEER) program from 1977 to 2005. During this period, the incidence of exocrine pancreatic cancer generally decreased whereas the incidence of endocrine pancreatic cancer increased. This difference in trends by histology was evident across age, gender, and racial groups. It was also evident among different racial/ethnic groups using data from 1992 to 2005. Variation in trends was observed by stage. The incidence of exocrine cancers declined for all stages except regional. Endocrine cancer incidence increased for all tumor stages, and the increase was most prominent for localized tumors. When exocrine tumors were stratified by tumor subsite, the incidence of cancers in the tail and body regions increased while the incidence in other regions decreased. While better detection and classification of tumors through improved diagnostic procedures may be related to these changing trends, etiologic factors warrant study.
对胰腺癌发病率的描述性研究一直很少，特别是在肿瘤组织学和分期方面。本研究的目的是通过监测、流行病学和最终结果（SEER）计划 1977 年至 2005 年的数据，按人口统计学和肿瘤特征检查外分泌和内分泌胰腺肿瘤的发病率趋势。在此期间，外分泌胰腺肿瘤的发病率普遍下降，而内分泌胰腺肿瘤的发病率上升。这种组织学趋势的差异在年龄、性别和种族群体中都很明显。1992 年至 2005 年的数据也表明了不同种族/民族群体之间的这种差异。不同分期的趋势也有所不同。除了局部肿瘤外，所有分期的外分泌癌发病率均下降。所有肿瘤分期的内分泌癌发病率均上升，局部肿瘤的发病率上升最为明显。当通过肿瘤亚部位对外分泌肿瘤进行分层时，尾部和体部区域癌症的发病率增加，而其他区域的发病率则下降。虽然通过改进诊断程序更好地检测和分类肿瘤可能与这些变化趋势有关，但病因因素仍需要研究。
