Institute of Pathology, Universitätsmedizin der Johannes Gutenberg-Universität, Langenbeckstrasse 1, Mainz, Germany,
Adv Biochem Eng Biotechnol. 2010;123:201-17. doi: 10.1007/10_2009_65.
Endothelial progenitor cells from peripheral blood or cord blood are attracting increasing interest as a potential cell source for cellular therapies aiming to enhance the neovascularization of tissue engineered constructs or ischemic tissues. The present review focus on a specific population contained in endothelial progenitor cell cultures designated as outgrowth endothelial cells (OEC) or endothelial colony forming cells from peripheral blood or cord blood. Special attention will be paid to what is currently known in terms of the origin and the cell biological or functional characteristics of OEC. Furthermore, we will discuss current concepts, how OEC might be integrated in complex tissue engineered constructs based on biomaterial or co-cultures, with special emphasis on their potential application in bone tissue engineering and related vascularization strategies.
外周血或脐血中的内皮祖细胞作为一种潜在的细胞来源，正越来越受到细胞治疗的关注，目的是增强组织工程构建物或缺血组织的新血管生成。本综述重点介绍内皮祖细胞培养物中一种特定的细胞群体，称为出芽内皮细胞（OEC）或外周血或脐血中的内皮集落形成细胞。特别关注目前已知的 OEC 的起源和细胞生物学或功能特征。此外，我们将讨论当前的概念，OEC 如何整合到基于生物材料或共培养的复杂组织工程构建物中，特别强调它们在骨组织工程和相关血管化策略中的潜在应用。
