Iverson Grant L, Brooks Brian L, Young Allan H
Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2A1,Canada.
Appl Neuropsychol. 2009 Jul;16(3):207-13. doi: 10.1080/09084280903098778.
The purpose of this study is to illustrate the clinical usefulness of a computerized neuropsychological battery for identifying neurocognitive deficits in adults with bipolar disorder. Participants were 47 outpatients with bipolar disorder who were individually matched on age, education, sex, and ethnicity to 47 control subjects from the Central Nervous System (CNS) Vital Signs normative database. CNS Vital Signs is comprised of seven common neuropsychological measures, and it generates 15 primary scores that are used to calculate five domain scores (Memory, Psychomotor Speed, Reaction Time, Cognitive Flexibility, and Complex Attention). There was a significant multivariate effect and statistically significantly worse scores for those in the bipolar group on all five domain scores (medium to large effect sizes). When using two or more scores below the fifth percentile as a cutoff for neurocognitive impairment, 42.6% of the bipolar sample and only 6.4% of the control sample scored in this range. A subset of outpatients with bipolar disorder has frank neurocognitive impairments identifiable with this 30-40-minute computerized assessment battery.
本研究的目的是阐明一种计算机化神经心理成套测验在识别双相情感障碍成人患者神经认知缺陷方面的临床实用性。研究参与者为47名双相情感障碍门诊患者，他们在年龄、教育程度、性别和种族方面与来自中枢神经系统（CNS）生命体征常模数据库的47名对照受试者进行了个体匹配。CNS生命体征由七种常见的神经心理测量方法组成，并生成15个主要分数，用于计算五个领域分数（记忆、心理运动速度、反应时间、认知灵活性和复杂注意力）。双相情感障碍组在所有五个领域分数上均存在显著的多变量效应，且得分在统计学上显著更差（效应大小为中等至大）。当使用两个或更多低于第五百分位数的分数作为神经认知损害的临界值时，42.6%的双相情感障碍样本和仅6.4%的对照样本得分在此范围内。一部分双相情感障碍门诊患者存在明显的神经认知损害，可通过这种30 - 40分钟的计算机化评估成套测验识别出来。
