Tanjung Mulyadi, Hakim Euis H, Mujahidin Didin, Hanafi Muhammad, Syah Yana M
Organic Chemistry Division, Institut Teknologi Bandung, Bandung, Indonesia.
J Asian Nat Prod Res. 2009 Nov;11(11):929-32. doi: 10.1080/10286020903302315.
A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC(50) values being 11.3, 6.0, and 5.1 microM, respectively.
从大戟科木薯叶的丙酮提取物中分离出一种新的法尼基化黄酮醇衍生物——大叶千斤拔素（1），以及两种已知的黄酮类化合物——asperin A（2）和芹菜素（3）。基于其光谱数据，包括紫外光谱、红外光谱、一维和二维核磁共振光谱以及高分辨电子轰击质谱，确定新化合物的结构为6-法尼基山奈酚。对化合物1-3进行了抗P-388细胞的细胞毒性评估，其半数抑制浓度（IC50）值分别为11.3、6.0和5.1微摩尔。
